Meaning & use

mutation

noun·Academic

Last updated

UK/mjuːˈteɪʃən/
US/mjuːˈteɪʃən/

Meanings

  1. nouncountablebiology

    A permanent change in an organism's genetic material that can be passed on to offspring.

    Grammar: Countable; can be used with 'a' or in the plural. Often followed by 'in'.

    Patterns

    • a mutation in a gene
    • cause a mutation
    • carry a mutation

    A mutation in the BRCA1 gene can increase the risk of certain cancers.

    Some mutations are harmless, while others cause genetic disorders.

    The virus accumulates mutations over time, making it harder to treat.

  2. nouncountable

    A significant and unexpected change in the form or nature of something.

    Grammar: Countable; often used with 'of' to show what changes.

    Patterns

    • a mutation of something
    • a mutation in something

    The company underwent a mutation in its business model after the crisis.

    The political system experienced a sudden mutation in the 1990s.

Word forms

pluralmutations

Common combinations

genetic mutation
Genetic mutations can lead to new traits in a species.
spontaneous mutation
Spontaneous mutations occur without any external cause.
carry a mutation
She carries a mutation that affects her metabolism.
mutation rate
The mutation rate of the virus is unusually high.

Synonyms and how they differ

alteration
More general; refers to any change, not specifically genetic.
change
Broad and neutral; does not imply a biological or sudden shift.
variation
Often refers to differences within a group, not a permanent genetic change.

Word family

mutate verb
To undergo or cause a genetic change.
mutant noun
An organism that has a mutation.
mutant adjective
Resulting from or showing a mutation.
mutational adjective
Relating to mutation.
mutability noun
The quality of being able to change.

Commonly confused: mutation or mutability? mutation or mutiny?

mutation vs mutability

Mutability is the general ability to change; a mutation is a specific change, especially in genes.

mutation vs mutiny

Mutiny is a rebellion, especially by sailors or soldiers, not a biological change.

Practice

The _____ in the gene caused the protein to be nonfunctional.

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